Wednesday House Blogging

Took a break from The Pretender long enough to watch AI and House last night. Mobster informant "John Smith" was suffering from Ornithine Transcarbamylase Deficiency, which is a deficincy in function of a key enzyme in the disposal of nitrogen.

When the body breaks up ingested proteins, the extras get turned into urea, which is then excreted in urine (mostly) and sweat. People with this disorder can't do that well, so they get toxic intermediates built up in their liver, and well, you can guess the rest.

According to this site, frequency of some form of the disease (it varies in severity) is 1:80,000 live births. Clinical onset is often rapid and devastating, and late-onset cases may start as late as 40-50. Also, and extremely interestingly, the disease is X-linked, and homozygous females (who don't have a normal copy of the gene) are often also severely mentally retarded. So House probably should have tested the brother's DNA (50% chance he had the same gene) for the disorder....

Who else was creeped out by the way Vogler was all over Cuddy? I would have totally torn him a new one about the difference between medical ethics and the bottom line. And whether or not it was his business if I had a crush on/ relationship with a coworker or not IN THE PAST.

Also, I cracked up at that whole "Do you like him? I mean like like him" conversation between Alison and Chase. That was SOOOO 7th grade.

Finally, we're hoping to see more of House's new Red '65 Corvette, which we have dubbed "Dr. House's P*ssy Wagon"......